The Axilla Region

Written by Dr Oliver Jones

Last updated December 15, 2025
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The Axilla Region - Podcast Version

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The axilla is a pyramidal region located inferior to the glenohumeral joint and shoulder girdle, at the junction of the upper limb and thoracic wall.

It acts as a passageway by which neurovascular and muscular structures enter and leave the upper limb.

In this article, we shall examine the anatomy of the axilla – the borders, contents, and any clinical correlations.

Anatomical illustration of the anterior view of the right axilla, displaying its pyramidal shape and six borders.

Fig 1
Anterior view of the right axilla region. Note the pyramidal shape, with 6 borders (or sides).


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Borders

The overall 3D shape of the axilla looks slightly like a pyramid. It consists of four walls, an apex, and a base:

  • Apex (axillary inlet) – it is bounded by the clavicle anteriorly, the first rib medially, and the superior border of the scapula posteriorly.
  • Lateral wall – formed by the intertubercular groove of the humerus, coracobrachialis muscle and short head of biceps brachii.
  • Medial wall – consists of the serratus anterior and the thoracic wall (ribs and intercostal muscles).
  • Anterior wall – contains the pectoralis major and the underlying pectoralis minor and the subclavius muscles.
  • Posterior wall – formed by the subscapularis, teres major and latissimus dorsi.

The size and shape of the axilla varies with arm position. Overhead abduction can contribute to narrowing of neurovascular passageways in susceptible individuals, increasing the risk of compression.

Transverse section of the axilla region highlighting its borders.

Fig 2
Transverse section of the axilla region.

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Contents

The contents of the axilla region include muscles, nerves, vessels, and lymphatics:

  • Axillary artery – the main artery supplying the upper limb. It is commonly referred as having three parts; one medial to the pectoralis minor, one posterior to pectoralis minor, and one lateral to pectoralis minor.
  • Axillary vein the main vein draining the upper limb. It is formed by the brachial veins and basilic vein, and receives the cephalic vein as a major tributary.
  • Brachial plexus – a network of spinal nerves (C5–T1) that gives rise to the peripheral nerves supplying the upper limb.
  • Axillary lymph nodes – a group of lymph nodes that filter lymph drained from the upper limb, breast, and pectoral region.
Illustration showing the anatomical structures of the axilla region.

Fig 3
Contents of the axilla region.


Passageways Exiting the Axilla

There are three main routes by which structures leave the axilla.

The main route of exit is immediately inferiorly and laterally, into the upper limb. The majority of contents of the axilla region leave by this method.

Another pathway is via the quadrangular space. This is a gap in the posterior wall of the axilla, allowing access to the posterior arm and shoulder area. Structures passing through include the axillary nerve and posterior circumflex humeral artery (a branch of the axillary artery.

The last passageway is the clavipectoral triangle, which is an opening in the anterior wall of the axilla. It is bounded by the pectoralis major, deltoid, and clavicle. The cephalic vein enters the axilla via this triangle.

Illustration of the boundaries and contents of the clavipectoral triangle in the axilla region.

Fig 4
Boundaries and contents of the clavipectoral triangle

Posterior view of the shoulder highlighting the quadrangular space with the subscapularis muscle obscured.

Fig 5
Posterior view of the shoulder region, showing the quadrangular space. The subscapularis muscle lies anteriorly, and so cannot be seen.

Clinical Relevance

Thoracic Outlet Syndrome

The apex of the axilla region is an opening between the clavicle, first rib and the scapula. In this apex, the vessels and nerves may become compressed between the bones – this is called thoracic outlet syndrome.

Common causes of thoracic outlet syndrome include:

  • Trauma – e.g. fractured clavicle.
  • Repetitive movements – seen commonly in occupations that require lifting of the arms.
  • Cervical rib – an extra rib which arises from the seventh cervical vertebra.

It often presents with pain in the affected limb (the distribution of pain is dependent on which nerve is compressed), tingling, muscle weakness and discolouration.

Lymph Node Biopsy

Approximately 75% of lymph from the breast drains into the axilla lymph nodes, so can be biopsied if breast cancer is suspected.

If breast cancer is confirmed, the axillary nodes may need to be removed to prevent the cancer spreading. This is known as axillary clearance. During this procedure, the long thoracic nerve may become damaged, resulting in winged scapula.

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