The Trochlear Nerve (CN IV)

Written by Anand Radhakrishnan

Last updated March 13, 2019 • 26 Revisions •

The trochlear nerve is the fourth paired cranial nerve. It is the smallest cranial nerve (by number of axons), yet has the longest intracranial course. It has a purely somatic motor function.

In this article, the anatomical course, motor functions and clinical relevance of the nerve will be examined.

Premium Feature

3D Model

Premium Feature
Access this feature with premium.
Go Premium

Anatomical Course

The trochlear nerve arises from the trochlear nucleus of the brain, emerging from the posterior aspect of the midbrain (it is the only cranial nerve to exit from the posterior midbrain).

It runs anteriorly and inferiorly within the subarachnoid space before piercing the dura mater adjacent to the posterior clinoid process of the sphenoid bone.

The nerve then moves along the lateral wall of the cavernous sinus (along with the oculomotor nerve, the abducens nerve, the ophthalmic and maxillary branches of the trigeminal nerve and the internal carotid artery) before entering the orbit of the eye via the superior orbital fissure.

Fig 1
The trochlear nerve and superior oblique muscle

Motor Function

The trochlear nerve innervates a single muscle – the superior oblique, which is a muscle of oculomotion. As the fibres from the trochlear nucleus cross in the midbrain before they exit, the trochlear neurones innervate the contralateral superior oblique.

The tendon of the superior oblique is tethered by a fibrous structure known as the trochlea, giving the nerve its name. Although the mechanism of action of the superior oblique is complex, in clinical practice it is sufficient to understand that the overall action of the superior oblique is to depress and intort the eyeball.

Fig 1.1 - Lateral view of the extraocular muscles.

Fig 2
Lateral view of the extraocular muscles.

Clinical Relevance

Examination of the Trochlear Nerve

The trochlear nerve is examined in conjunction with the oculomotor and abducens nerves by testing the movements of the eye.

The patient is asked to follow a point (commonly the tip of a pen) with their eyes without moving their head. The target is moved in an ‘H-shape’ and the patient is asked to report any blurring of vision or diplopia (double vision).

Palsy of the Trochlear Nerve

Trochlear nerve palsy commonly presents with vertical diplopia, exacerbated when looking downwards and inwards (such as when reading or walking down the stairs). Patients can also develop a head tilt away from the affected side.

They are commonly caused by microvascular damage from diabetes mellitus or hypertensive disease. Other causes include congenital malformation, thrombophlebitis of the cavernous sinus, and raised intracranial pressure.

Fig 3
Left trochlear nerve palsy, characterised by vertical diplopia and head tilt away from the affected side.

Do you think you’re ready? Take the quiz below

Premium Feature


The Trochlear Nerve (CN IV)

Question 1 of 3

Rate question:
You scored
Skipped: 0/3
Make sure you're ready by unlocking all available questions.
Go Premium