Development of the Urinary System
The main functions of the urinary system include:
- Removal of metabolic waste products such as uric acid, urea and creatinine.
- Maintain electrolyte, water and pH balance.
- Regulation of blood pressure, blood volume and erythropoiesis, and vitamin D production.
Development of the urinary system is closely related to the development of the reproductive system; particularly during the earlier stages – where they develop from the same origin. However, the urinary system develops ahead of the reproductive system.
The urinary system consists of the kidneys, ureters, bladder and urethra. A region of intermediate mesoderm, known as the urogenital ridge, gives rise to these structures.
In this article, we will look at the embryology of the urinary system and its clinical correlations.
Development of the Kidneys
In the embryo, the kidneys develop from three overlapping sequential systems; the pronephros, the mesonephros, and the metanephros. They are all derived from the urogenital ridge.
The pronephros appears in the 4th week of development.
Its development begins in the cervical region of the embryo. Segmented divisions of intermediate mesoderm form tubules, known as nephrotomes. In total, 6-10 pairs of nephrotomes are formed.
These tubules join into the pronephric duct, which is a duct that extends from the cervical region to the cloaca (distal end) of the embryo. This early system is non-functional and regresses completely by the end of week 4.
The mesonephros develops caudally (inferiorly) to the pronephros. First, the presence of the pronephric duct induces nearby intermediate mesoderm in the thoracolumbar region to form mesonephric tubules.
These tubules receive a tuft of capillaries from the dorsal aorta – allowing for the filtration of blood – and they drain into the mesonephric duct (a continuation of the pronephric duct). They act as a primitive excretory system in the embryo, with most tubules regressing by the end of the 2nd month.
Additionally, the mesonephric duct sprouts the ureteric bud caudally, which induces the development of the definitive kidney.
The metanephros forms the definitive kidney. It appears in the 5th week of development and becomes functional around the 12th week.
The ureteric bud from the mesonephric duct makes contact with a caudal region of intermediate mesoderm – the metanephric blastema (Fig 2). Collectively, these blastema form the metanephric system, which has two components:
- Collecting system – derived from the ureteric bud.
- It dilates to create the ureter, renal pelvis, major and minor calyces and collecting tubules – terminating at the distal convoluted tubule.
- If the uretic bud splits too early, two ureters, or two renal pelvices connecting to one ureter may result.
- Excretory system – derived from the metanephric blastema.
- Each collecting tubule from the collecting system is covered by a metanephric tissue cap which gives rise to the excretory tubules.
- These excretory tubules (along with the developing glomeruli) form the kidney’s functional units – the nephron.
- The proximal end of the excretory tubule forms the Bowman’s capsule around a glomerulus, while the distal end elongates to form the proximal convoluted tubule, loop of Henle and distal convoluted tubule
The definitive kidney initially develops in the pelvic region before ascending into the abdomen. In the pelvis, the kidney receives its blood supply from a pelvic branch of the abdominal aorta and as it ascends, new arteries from the abdominal aorta supply the kidney. The pelvic vessels usually regress, but can persist as accessory renal arteries.
Clinical Relevance: Horseshoe Kidney
A horseshoe kidney (also known as a cake kidney or fused kidney) is where the two developing kidneys fuse into a single horseshoe-shaped structure.
This occurs if the kidneys become too close together during their ascent from the pelvis to the abdomen – they become fused and consequently ‘stuck’ underneath the inferior mesenteric artery.
This type of kidney is still drained by two ureters, and is usually asymptomatic, although it can be prone to obstruction.
Development of the Bladder and Urethra
The bladder and urethra of the urinary system are ultimately derived from the cloaca – a hindgut structure that is a common chamber for gastrointestinal and urinary waste.
In the 4th-7th weeks of development, the cloaca is divided into two parts by the uro-rectal septum:
- Urogenital sinus (anterior) – divided into three parts:
- The upper part of the urogenital sinus forms the bladder.
- The pelvic part forms the entire urethra and some of the reproductive tract in females, and the prostatic and membranous urethra in males.
- The phallic/caudal part forms part of the female reproductive tract, and the spongy urethra in males.
- Anal canal (posterior)
The urinary bladder is initially drained by the allantois. However, this is obliterated during fetal development and becomes a fibrous cord – the urachus. A remnant of the urachus can be found in adults; the median umbilical ligament, which connects the apex of the bladder to the umbilicus.
As the bladder develops from the urogenital sinus, it absorbs the caudal parts of the mesonephric ducts (also known as the Wolffian ducts), becoming the trigone of the bladder. The ureters, which have formed as outgrowths of the mesonephric ducts, enter the bladder at the base of the trigone. The final structure varies between sexes: