The Adrenal Glands

Anatomical Location and Relations

The adrenal glands are located in the posterior abdomen, between the superomedial kidney and the diaphragm. They are retroperitoneal, with parietal peritoneum covering their anterior surface only.

The right gland is pyramidal in shape, contrasting with the semi-lunar shape of the left gland.

Perinephric (or renal) fascia encloses the adrenal glands and the kidneys. This fascia attaches the glands to the crura of the diaphragm. They are separated from the kidneys by the perirenal fat.

The adrenal glands sit in close proximity to many other structures in the abdomen:

By TeachMeSeries Ltd (2025)

Fig 2
Posterior view of the abdomen, demonstrating the anatomical relations of the adrenal glands.

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Anatomical Structure

The adrenal glands consist of an outer connective tissue capsule, a cortex and a medulla. Veins and lymphatics leave each gland via the hilum, but arteries and nerves enter the glands at numerous sites.

The outer cortex and inner medulla are the functional portions of the gland. They are two separate endocrine glands, with different embryological origins:

• Cortex – derived from the embryonic mesoderm.
• Medulla – derived from the ectodermal neural crest cells.

The cortex and medulla synthesise different hormones.

Cortex

The cortex is yellowish in colour. It secretes two cholesterol derived hormones – corticosteroids and androgens. Functionally, the cortex can be divided into three regions (superficial to deep):

• Zona glomerulosa – produces and secretes mineralocorticoids such as aldosterone.

• Zona fasciculata – produces and secretes corticosteroids such as cortisol. It also secretes a small amount of androgens.

• Zona reticularis – produces and secretes androgens such as dehydroepiandrosterone (DHES). It also secretes a small amount of corticosteroids.

By TeachMeSeries Ltd (2025)

Fig 3
Histological appearance of the cortex and medulla of the adrenal gland.

Medulla

The medulla lies in the centre of the gland, and is dark brown in colour. It contains chromaffin cells, which secrete catecholamines (such as adrenaline) into the bloodstream in response to stress.

These hormones produce a ‘flight-or-fight‘ response. Chromaffin cells also secrete enkephalins which function in pain control.

Vasculature

The adrenal glands have a rich blood supply via three main arteries:

• Superior adrenal artery – arises from the inferior phrenic artery
• Middle adrenal artery – arises from the abdominal aorta.
• Inferior adrenal artery – arises from the renal arteries.

Right and left adrenal veins drain the glands. The right adrenal vein drains into the inferior vena cava, whereas the left adrenal vein drains into the left renal vein.

Innervation

The adrenal glands are innervated by the coeliac plexus and greater splanchnic nerves.

Sympathetic innervation to the adrenal medulla is via myelinated pre-synaptic fibres, mainly from the T10 to L1 spinal cord segments.

Lymphatics

Lymph drainage is to the lumbar lymph nodes by adrenal lymphatic vessels. These vessels originate from two lymphatic plexuses – one deep to the capsule, and the other in the medulla.

Clinical Relevance

Pheochromocytoma

A pheochromocytoma is a tumour of the adrenal medulla or preganglionic sympathetic neurones. It secretes adrenaline and noradrenaline uncontrollably, causing blood pressure to greatly increase. Patients may present with palpitations, headaches and diaphoresis (profuse sweating).

Phenoxybenzamine, a competitive, irreversible antagonist of adrenaline, can be used in treatment to reduce blood pressure by binding to adrenaline receptors, making less available for adrenaline to act upon.

By TeachMeSeries Ltd (2025)

Fig 4
CT scan of a pheochromocytoma.