The Small Intestine

Original Author: Oliver Jones
Last Updated: January 27, 2018
Revisions: 28

The small intestine is an organ located within the gastrointestinal tract. It assists in the digestion and absorption of ingested food.

It extends from the pylorus of the stomach to the iliocaecal junction, where it meets the large intestine. Anatomically, the small bowel can be divided into three parts; the duodenum, jejunum and ileum.

In this article, we shall examine the anatomy of the small intestine – its structure, neurovascular supply and any clinical correlations.

Fig 1.0 - The anatomical divisions of the small intestine.

Fig 1 – The anatomical divisions of the small intestine.

The Duodenum

The most proximal portion of the small intestine is the duodenum. Its name is derived from the Latin ‘duodenum digitorum’, meaning twelve fingers length. It runs from the pylorus of the stomach to the duodenojejunal junction.

The duodenum can be divided into four parts; superior, descending, inferior and ascending. Together these parts form a ‘C’ shape, which wraps around the head of the pancreas.

Superior (L1)

The first section of the duodenum (‘the cap’) is 5cm in length. It ascends upwards from the pylorus of the stomach, and is connected to the liver by the hepatoduodenal ligament. This area is most common site of duodenal ulceration.

The initial 3cm of the superior duodenum is covered anteriorly and posteriorly by visceral peritoneum, with the remainder retroperitoneal (only covered anteriorly).

Descending (L1-L3)

The descending portion curves inferiorly around the head of the pancreas. It lies posteriorly to the transverse colon, and anterior to the right kidney.

Internally, the descending duodenum is marked by the major duodenal papilla – an opening for bile and pancreatic secretions to enter. The duct responsible carrying these secretions is known as the ampulla of Vater (hepatopancreatic ampulla).

Inferior (L3)

The inferior duodenum travels laterally to the left, crossing over the inferior vena cava and aorta. It is located inferiorly to the pancreas, and posteriorly to the superior mesenteric artery and vein.

Ascending (L3-L2)

After the duodenum crosses the aorta, it ascends and curves anteriorly to join the jejunum at a sharp turn known as the duodenojejunal flexure.

Located at the duodenojejunal junction is a slip of muscle called the suspensory muscle of the duodenum. Contraction of this muscle widens the angle of the flexure, and aids movement of the intestinal contents into the jejunum.

Fig 2 - The different parts of the duodenum. The liver, gall bladder and transverse colon have been removed.

Fig 2 – The different parts of the duodenum. The liver, gall bladder and transverse colon have been removed.

Clinical Relevance: Duodenal Ulcers

A duodenal ulcer is the erosion of the mucosa in the duodenum. It is also known as a peptic ulcer (although this term can also be used to refer to ulcerations in the stomach). Duodenal ulcers are most likely to occur in the superior portion of the duodenum.

The most common causes of duodenal ulcers are helicobacter pylori infection and chronic NSAID therapy.

An ulcer in itself is not particularly troublesome. However, it can give rise to some serious complications if the duodenal wall is perforated:

  • Inflammation of the peritoneum (peritonitis) – causing damage to the surrounding viscera, such as the liver, pancreas and gall bladder.
  • Erosion of the gastroduodenal artery – causing haemorrhage and potential hypovolaemia shock.

Jejunum and Ileum

The jejunum and ileum are the distal two parts of the small intestine. In contrast to the duodenum, they are intraperitoneal.

They are attached to the posterior abdominal wall by mesentery (a double layer of peritoneum).

The jejunum begins at the duodenojejunal flexure. There is no clear external demarcation between the jejunum and ileum – although the two parts are macroscopically different. The ileum ends at the ileocecal junction.

At this junction, the ileum invaginates into the cecum to form the ileocecal valve. Although it is not developed enough to control movement of material from the ileum to the cecum, it can prevent reflux of material back into the ileum

Fig 3 – The ileocecal junction

Clinical Relevance: Characteristic Features of the Jejunum and Ileum

During surgery, it is often necessary to be able to distinguish between the jejunum and ileum of the small intestine:

Jejunum Ileum
Located in upper left quadrant Located in lower right quadrant
Thick intestinal wall Thin intestinal wall
Longer vasa recta (straight arteries) Shorter vasa recta
Less arcades (arterial loops) More arcades
Red in colour Pink in colour

Vasculature and Lymphatics


The arterial supply of the duodenum is derived from two sources:

  • Proximal to the major duodenal papilla – supplied by the gastroduodenal artery (branch of the coeliac trunk).
  • Distal to the major duodenal papilla – supplied by the inferior pancreaticoduodenal artery (branch of superior mesenteric artery).

This transition is important – it marks the change from the embryological foregut to midgut. The veins of the duodenum follow the major arteries and drain into the hepatic portal vein.

Lymphatic drainage is to the pancreatoduodenal and superior mesenteric nodes.

Jejunum and Ileum

The arterial supply to the jejunoileum is from the superior mesenteric artery.

The superior mesenteric artery arises from the aorta at the level of the L1 vertebrae, immediately inferior to the coeliac trunk. It moves in between layers of mesentery, splitting into approximately 20 branches. These branches anastomose to form loops, called arcades. From the arcades, long and straight arteries arise, called vasa recta.

The venous drainage is via the superior mesenteric vein. It unites with the splenic vein at the neck of the pancreas to form the hepatic portal vein.

Lymphatic drainage is into the superior mesenteric nodes.

Fig 3 - Arterial supply to the jejunum and ileum of the small intestine

Fig 4 – Arterial supply to the jejunum and ileum of the small intestine

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Question 1 / 11
Which of the following describes the three parts of the small intestine, in order, from stomach to large intestine


Question 2 / 11
Where does the small intestine start and finish?


Question 3 / 11
What is the approximate length of the superior duodenum?


Question 4 / 11
What connects the superior duodenum to the liver?


Question 5 / 11
Which of the following vessels lie posteriorly to the inferior duodenum?


Question 6 / 11
What widens the angle of the duodenojejunal junction to allow passage of intestinal contents?


Question 7 / 11
Which of these is not a cause of duodenal ulcers?


Question 8 / 11
In what quadrant of the abdomen is the ileum mainly located in?


Question 9 / 11
Which of these is not a characteristic feature of the jejunum when compared to the ileum?


Question 10 / 11
What name is given to the part of the duodenum highlighted in yellow?


Question 11 / 11
What term is given to the area of the duodenum highlighted in blue?


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